Safety of marijuana
‘You can find no established printed cases world wide of human deaths from weed poisoning, and the amount of THC needed to produce 50% death in rats is extremely large compared with other widely used drugs.’
There are medical reports of unexpected infarction, stroke and other cardiovascular area effects. Marijuana’s cardiovascular effects aren’t associated with serious health problems for many young, balanced users. Researchers have noted in the International Journal of Cardiology, ‘Marijuana use by seniors, particularly those with some degree of coronary artery o-r cerebrovascular illness, poses greater dangers due to the resulting escalation in catecholamines, cardiac work, and carboxyhemoglobin levels, and concurrent periods of profound postural hypotension. Indeed, pot might be a much more common reason behind myocardial infarction than is generally known. In day-to-day practice, a brief history of marijuana use is usually not sought by many practitioners, and even if sought, the patient’s reaction isn’t always genuine. Ergo, clinicians must be more vigilant in asking about utilization of marijuana in their patients, specially among younger people who may present with cardiac events in the lack of cardiovascular disease or other apparent danger factors.’
The researchers discovered ‘Occasional and low collective marijuana use wasn’t related to adverse effects on pulmonary function.’ Smoking typically one joint every day for seven years, they found, did not worsen pulmonary health.
Cannabis smoke contains 1000s of organic and inorganic compounds. This tar is chemically similar to that found in tobacco smoke or cigars. Over fifty known carcinogens have now been discovered in marijuana smoke. These generally include reactive aldehydes, nitrosamines, and polycylic hydrocarbons, including benz[a]pyrene. Marijuana smoke was listed as a agent in California in 2009.
When adjusting for many confounding factors including using tobacco and alcohol use. A 2006 study involving 1,212 event cancer cases and 1,040 cancer-free controls found no causative link to oral, laryngeal, pharyngeal, esophageal o-r lung cancer
‘There is no record in the extensive medical literature describing an established, reported cannabis-induced fatality….Despite [a] long record of use and the extremely high variety of social smokers, there are simply no legitimate medical studies to suggest that consuming pot has caused a single death. In practical terms, marijuana can’t induce a deadly response as a result of drug-related toxicity….Marijuana’s therapeutic ratio is difficult to assess because it is indeed high….Marijuana, in its normal form, is among the safest therapeutically active substances known to man.’
The effectiveness of marijuana as an analgesic has-been the subject of numerous studies. University of Oxford health practitioners found that the brain o-n THC showed reduced response to pain, suggesting that the drug may help individuals withstand pain. Brain scans showed paid down activity in two centers of-the mind where pain is registered: The mid-Anterior cingulate cortex and the best Amygdala.
According to Stuart Silverman, M.D., a rheumatologist at Cedars-Sinai Medical Center, ‘Historically and anecdotally, pot has been used as a painkiller.’ A Canadian study showed marijuana can reduce ‘nerve pain’ from surgical complications or incidents. The study’s twenty-one subjects experienced persistent pain and patients who smoked marijuana with a THC information reported less pain than those patients who smoked the placebo. Grant explained further that not everybody experienced pain relief, but the proportion of people who did was similar to those who said that they experienced relief from other drugs commonly prescribed for neuropathic pain (the topic of his study), including antidepressants.
A small-scale UCSF research found that patients with chronic pain may possibly experience greater comfort if cannabinoids were put into an opiate-only treatment plan. published a report within the Neuropsychopharmacology record in 2013 that’s predicated on re-search that was conducted with fifteen men and fifteen females who smoked pot everyday. The study’s subjects were exposed to the placebo, inhaled pot, or dronabinol, a pill that contains marijuana’ psychoactive ingredient. Players were checked to ensure they had not reviewed in the time frame straight away before the tests and did not have other drugs (including alcohol) within their programs. The researchers concluded that ‘Dronabinol management decreased pain sensitivity and increased pain tolerance that peaked later and lasted longer in accordance with smoked weed’, thus providing evidence that the pill form was better than smoked weed when it comes to pain relief efficiency. But, the Columbia scientists further stated, ‘A major caveat of the current findings is that the study population consisted of everyday marijuana smokers; this study restriction should be considered when interpreting the findings and putting them within the framework of the possible beneficial feasibility of cannabinoids [for the basic population].’
Medical cannabis in edible form
In glaucoma, THC and marijuana have been shown to lessen pres-sure (IOP) by on average twenty-four hours a day in individuals with normal IOP who have visual-field changes. In studies of healthy adults and glaucoma patients, IOP was reduced by an of 25% after smoking a cannabis ‘cigarette’ that covered about 2% THC—a decline as effective as that observed with almost every other medications available today, based on an assessment by the Institute of Medicine.
In a separate study, the use of cannabis and glaucoma was examined and found that the length of smoked or ingested cannabis or other cannabinoids is very short, averaging 3 to 3.5 hours. Their results showed that for cannabis to become a viable therapy, the individual will have to consume cannabis in a few sort every 3 hours. They stated that for ideal glaucoma therapy it’d take 2 times a day at most for compliance purposes from patients.
Spasticity in multiple sclerosis
The authors postulated that ‘cannabinoids may offer neuroprotective and anti-inflammatory benefits in MS.’ A little study done on whether cannabis might be used to get a grip on tremors of MS patients was performed. The study found that there is no noticeable difference of the tremors in the individuals. While there is no difference in the tremors the patients felt as if their symptoms had reduced and their standard of living had improved. The researchers concluded that the mood enhancing o-r cognitive consequences that cannabis has on the mind might have given the individuals the consequence that their tremors were getting better.
Cannabinoids present in medical cannabis prevent o-r inhibit the development of Alzheimer’s disease.
Research done by the Scripps Research Institute in California demonstrates the ingredient in marijuana, THC, prevents the synthesis of deposits in the brain connected with Alzheimer’s disease. THC was found to prevent an called acetylcholinesterase from accelerating the formation of ‘Alzheimer plaques’ in-the head more effectively than commercially sold drugs.
A 2012 critique from the Philosophical Transactions of a Society B suggested that initiating the cannabinoid system might trigger an ‘anti-oxidant cleanse’ in the brain by eliminating damaged cells and increasing the efficiency of the mitochrondria. The review found cannabinoids might slow decline in age and disease-related mental functioning.
Medical pot blocks the spread of breast cancer by downregulating a gene called ID1.
Human trial models are in development. Dr Sean McAllister, study co-leader, commented:
‘The pre-clinical trial information is extremely strong, and there’s no toxicity. There is actually a great deal of research to go forward with and to have people excited.’
Medical cannabis really helps to relieve pain and to improve quality of life for HIV-positive patients.
Researchers at Columbia University published clinical trial data in 2007 showing that HIV/AIDS people who inhaled cannabis four times daily experienced large increases in diet with little evidence of discomfort and no impairment of intellectual performance. Physical disability, feeling interference, and quality of life all increased significantly throughout research treatment. Despite management with opioids and other pain altering solutions, neuropathic pain continues to reduce the quality of life and daily functioning in individuals. Cannabinoid receptors in-the central and peripheral nervous systems have been shown to modulate pain perception. No serious negative effects were noted, according to the study published by the American Academy of Neurology. A study examining the performance of various drugs for HIV associated neuropathic pain found that smoked Cannabis was one of only three drugs that showed proof of efficacy.
THC found in marijuana eliminates brain cancer while leaving healthy brain cells intact.
The study group found that cannabinoids such as for instance THC had anti-cancer effects in mice with human brain cancer cells and in people with brain tumors. When rats with the mind cancer cells received the THC, the tumor shrank. Using electron microscopes to assess mind tissue taken both before and after a 26-to 30-day THC treatment program, the scientists found that THC eliminated cancer cells while leaving healthy cells intact. The patients didn’t have any toxic effects from the treatment; previous reports of THC for the treatment of cancer have also found the treatment to be well tolerated.
Medical weed pays to in the prevention and treatment of opiate dependence.
When these rats were used THC, they no more created regular morphine-dependent behavior. In the striatum, a spot of the brain involved with drug dependency, the production of endogenous enkephalins was restored under THC, although it decreased in rats pressured from birth which had not received THC. Experts believe the findings can lead to therapeutic solutions to current substitution treatments.
Preventing ALS symptoms
Medical pot is reasonably successful in reducing symptoms of Amyotrophic lateral sclerosis (ALS) (Lou Gehrig’s Infection ).
The possible role of marijuana in treating indicators of ALS (or Lou Gehrig’s Disease) continues to be the topic of new re-search. A survey was conducted o-n 131 people experiencing ALS. The study asked if the subjects had used marijuana within the last 12-months to regulate some of their symptoms. Of the 131 subjects, 13 had used the drug in a few kind to control symptoms. The survey discovered that marijuana was reasonably effective in reducing symptoms of appetite loss, pain, depression, spasticity, drooling and weakness, and the greatest relief described was for depression. The pattern of symptom relief was consistent with those described by people with other problems, including multiple sclerosis (Amtmann et al. 2004 ).
Research published on May possibly 6, 2013 within the journal Clinical Gastroenterology and Hepatology unveiled that subjects with Crohn’s Illness experienced advantages from puffed cannabis use. In the end of the study’s treatment time, five out of the eleven patients that received pot treatment shown significant changes in disease-related symptoms, while five of these patients experienced complete remission.